Hesperidin Methyl Chalcone

Hesperidin Methyl Chalcone is a flavanone glycoside (flavonoid) (C28H34O15) found abundantly in citrus fruits.

Its aglycone form is called hesperetin. Hesperidin and methyl hesperidin reduce TNF-alpha-induced VCAM-1

expression through inhibiting the phosphorylation of Akt and PKC.  Methyl hesperidin can bind to buman serum

albumin (BSA) with binding constants between 18 and 34 mM/L.  Long-term carcinogenicity study demonstrates

that methyl hesperidin shows no carcinogenicity for B6C3F1 mice in the 96-wk feeding regimen.